About SNP Genotyping with Personalized medicine
Osmf with UIceration treated with Curcumin
Pre Treatment Image
After two weeks of treatment with Curcumin, SNP detected was TNF alpha 238 in the case
Advances in molecular medicine have spawned the newer field of pharmacogenomics, which seeks to understand all of the molecular underpinnings of drug response.
Shifting emphasis in medicine from reaction to prevention.
Enabling the selection of optimal therapy and reducing trial-and-errorprescribing.
Making the use of drugs safer by avoiding adverse drug reactions.
Increasing patient compliance with treatment
Reducing the overall cost of health care
new tools to decode the human genome more rapidly and accurately using physically smaller yet more powerful machines.
large-scale studies and sample repositories that help link genetic variations to disease across many countries and continents.
real-world examples of hospitals, regional health care systems, and educational institutions promoting clinical adoption of PM through research, clinical practice, and medical education reform.
various natural compounds showing most negetive binding energy with the causative SNP than the current chemotherapeutic drugs. The compound which is very affective for a particular disease with a particular SNP is not very affective for same disease with another SNP. This can answer the question why the same drug will not show equal affect in different individuals with same disease.
For example, an OSMF patient treated with Curcumin showed good binding and prognosis when SNP involved was cytochrome 450, whereas on the other hand the same Curcumin was ineffective when SNP involved was HSP 47.
HAS 47
| Pentoxyfylline | Asn66, His315, Asp316 | -5.01 | 213.500 |
| Levamisole | His 315 | -5.21 | 152.52 |
| Dexamethasone | His315, Asp316(2) | -5.51 | 92.07 |
| Hyaluronidase | His 315, Asp316 | -4.87 | 270.82 |
| Tnamcinolone acetonide | Thr314, His315 | -6.16 | 30.67 |
| Curcumin | Trp128, Ser399, Thr127 | -2.01 | 33.84 |
Binding of Curcumin is better then regular Chemotherapeutic drugs which are used to treat Lichenplanus case, when involved gene is TNF alpha238
| Curcumin | -6.34 | 22.51 µM | Arg6, Lys11, His15, Tyr59 |
| Clobetasol propionate | -6.09 | 34.32 µM | Arg6, Ala33, Arg31, Ala35, Leu37 |
| Triamcinolone | -5.78 | 58.37 µM | Arg6, Arg32, Ala33, Ala35, Leu379(2) |
| Tritinoin | -5.44 | 103.07 µM | Asn34 |
